Laureates of the Japan Prize

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Dr. C. David Allis

2014 (30th) Japan Prize Laureate

Field
Life Science
Achievement
Discovery of histone modifications as fundamental regulators of gene expression
Commemorative Lecture
Beyond the double helix: varying the terrain of epigenetic landscapes in development & disease
Nationality: United States of America
Date of Birth: March 22, 1951
Academic Degrees:
1973 University of Cincinnati, B.S. in Biology
1975 Indiana University, M.S. in Biology
1978 Indiana University, Ph.D. in Biology
Professional Career:
1978-1981 Post Doctoral Fellow, the University of Rochester
1981-1990 Assistant, Associate and Professor, Dept. of Biochemistry and Cell Biology,Baylor College of Medicine
1990-1995 Professor, Dept. of Biology, Syracuse University
1995-1998 Marie and Joseph Wilson Professor of Biology and Professor of Oncology, University of Rochester
1998-2003 Harry F. Byrd, Jr. Professor of Biochemistry and Molecular Genetics, Professor of Microbiology and Member of the Center for Cell Signaling, University of Virginia Health System
2003-Present Joy and Jack Fishman Professor and Head of the Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University
Major Publications:
  1. Brownell, J.E., and Allis, C.D. Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell 84, 843-851, doi:S0092-8674(00)81063-6 [pii] (1996).
  2. Sassone-Corsi, P., Mizzen, C.M., Cheung, P., Crosio, C., Monaco, M., Jacquot, S., Hanauer, A., and Allis, C.D. Requirement of Rsk-2 for epidermal growth factor- activated phosphorylation of histone H3. Science 285, 886-891, doi:7736 [pii] (1999).
  3. Strahl, B. D. and Allis, C. D. The language of covalent histone modifications. Nature 403, 41-45, doi:10.1038/47412 (2000).
  4. Jenuwein, T. and Allis, C.D. Translating the histone code. Science 293, 1074-1080 (2001).
  5. Wysocka, J., Swigut, T., Xiao, H., Landry, J., Kauer, M., Tackett, A., Chait, B., Brivanlou, A.H., Wu, C. and Allis, C.D. A PHD finger in the largest subunit of NURF couples histone H3 K4 trimethylation with chromatin remodeling. Nature 442, 86-90, PMID: 16728978 (2006).
  6. Wang, G.G., Song, J., Wang, Z., Dormann, H., Casadio, F., Li, H., Patel, D. and Allis, C.D. Haematopietic malignancies initiated by dysregulation of an H3K4me3-engaging PHD finger. Nature 459, 847-851, PMID: 19430464 (2009).
  7. Goldberg A.D., Banaszynski L.A., Noh K.M., Lewis P.W., Elsässer S.J., Stadler S., Dewell S., Law M., Guo X., Li X., Wen D., Chapgier A., DeKelver, R.C., Miller J.C., Lee Y.L., Boydston E.A., Holmes M.C., Gregory P.D., Greally J.M., Rafii S., Yang C., Scambler P.J., Garrick D., Gibbons R.J., Higgs D.R., Cristea I.M., Urnov F.D., Zheng D., Allis C.D. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell 140, 678-691, PMID: 20211137 (2010).
  8. Lewis, P.W., Mueller, M.M., Koletsky, M.S., Cordero, F., Lin, S., Banaszynski, L.A., Garcia, B.A., Muir, T.W., Becher, O.J. and Allis C.D. Inhibition of PRC2 activity by gain-of-function mutations in pediatric glioblastoma mutation. Science 17, 857-861, PMID: 23539183 (2013).
Major Awards:
  • 2002 Dickson Prize in Biomedical Sciences
  • 2003 Massry Prize
  • 2007 Gairdner Foundation International Award
  • 2008 ASBMB-Merck Award
  • 2011 Lewis S. Rosenstiel Award

( At the time of receipt of the Prize )

More about the Laureates

30 Years of Japan Prize

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