Japan Prize Laureates

Laureates of the Japan Prize

Prof. Alain Fischer

Alain Fischer, M.D., Ph.D.

  • Nationality:
    France
  • Date of Birth:
    11 September 1949

Outline of Achievements

Outline of Achievements

The 2015 Japan Prize

Major Honors

1984 Halpern Prize
1992 Prix Behring-Metchnikoff
1994 Prix du Comité du Rayonnement français
1998 Jung Prize for Medicine (Hamburg)
2000 Prix Pierre Royer
2000 NRJ Foundation – Institut de France – Award
2001 Joint winner of the Louis-Jeantet Prize for Medicine
2001 Novartis Prize for Clinical Immunology
2003 A. Philipson Prize (Stockholm)
2005 Honorary Degree of the University of Zurich
2005 Descartes Prize (European Community)
2008 INSERM Grand Prix
2010 Officier de la Légion d'honneur
2011 Senior advanced grant from ERC (European Research Council)
2012 Avery Landsteiner prize
2013 Grand prix Claude Bernard de la ville de Paris
2013 Sanofi-Pasteur prize
2014 Robert Koch prize

Memberships

2002 Member of the European Molecular Biology Organization
2002 Member of the French Academy of Science
2009 Member of the Academia Europea

Academic Degrees

1979 M.D. from Université Paris Descartes
1979 Ph.D. from Université Paris Jussieu

Professional Career

1980-1981 Postdoctoral fellowship in Immunology at University College London
1981-1991 Group leader – Institut national de la santé et de la recherche médicale (INSERM) Unit 132, Hôpital Necker-Enfants malades, Paris
1984-1988 Tenured clinical position in the Pediatric Immunology Department, Hôpital Necker-Enfants malades
1988-2013 Professor of Pediatric Immunology (Université Paris Descartes)
1991-2013 Director of INSERM Unit 768 for “Développement Normal et Pathologique du Système Immunitaire (Normal and pathological development of the immune system),” Hôpital Necker-Enfants malades, Université Paris Descartes
1996-2012 Director of Pediatric Immunology Department, Hôpital Necker-Enfants malades
2006-present Professor at Institut Universitaire de France
2007-present Director of Institut Imagine (Institut des maladies génétiques), Hôpital Necker-Enfants malades, Université Paris Descartes, Inserm U1163
2014-present Professor at Collège de France (chaire de médecine expérimentale)

Affiliation

  • Institut Imagine
    24 Boulevard Montparnasse
    785015 Paris, France

Major Publications

  • Stephan V, Wahn V, Le Deist F., Dirksen U, Broker B., Muller-Fleckenstein I, Horneff G. Schroten H., Fischer A, de Saint Basile G. Atypical X-linked severe combined immunodeficiency due to possible spontaneous reversion of the genetic defect in T cells. New Engl J Medecine 335(21):1563-1567, 1996
  • Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, Gross F, Yvon E, Nusbaum P, Selz F, Hue C, Certain S, Casanova JL, Bousso P, Deist FL, Fischer A. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288(5466): 669-672, 2000.
  • Hacein-Bey-Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, De Villartay JP, Thrasher AJ, Wulffraat N, Sorensen R, Dupuis-Girod S, Davies EG, Kuis W, Leiva L, Fischer A, Cavazzana-Calvo M. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med 346(16): 1185-1193, 2002.
  • Hacein-Bey-Abina S, von Kalle C, Schmidt M, Le Deist F, Wulffraat N, McIntyre E, Radford I, Villeval JL, Fraser CC, Cavazzana-Calvo M, Fischer A. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 348(3): 255-256, 2003.
  • Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A*, Cavazzana-Calvo M*. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302(5644): 415-419, 2003. * cosenior authors
  • Hacein-Bey-Abina S, Hauer J, Lim A, Picard C, Wang GP, Berry CC, Martinache C, Rieux-Laucat F, Latour S, Belohradsky BH, Leiva L, Sorensen R, Debré M, Casanova JL, Blanche S, Durandy A, Bushman FD, Fischer A*, Cavazzana-Calvo M*. Efficacy of gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 363(4): 355-364, 2010. * cosenior authors
  • Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Bleesing J, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, de Oliveira S, Fernandez KS, Guo D, Harris CE, Hopkins G, Lehmann LE, Lim A, London WB, van der Loo JC, Malani N, Male F, Malik P, Marinovic MA, McNicol AM, Moshous D, Neven B, Oleastro M, Picard C, Ritz J, Rivat C, Schambach A, Shaw KL, Sherman EA, Silberstein LE, Six E, Touzot, Tsytsykova A, Xu-Bayford J, Baum C, Bushman FD*, Fischer A*§, Kohn DB*, Filipovich AH*, Notarangelo LD*, Cavazzana M*, Williams DA*§, Thrasher AJ*. A modified gamma-retrovirus vector for X-linked severe combined immunodeficiency. News Engl J Med 371(15):1407-1417,2014* cosenior authors; § cocoresponding authors
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