Laureates of the Japan Prize

photo

Alain Fischer, M.D., Ph.D.

2015 (31st) Japan Prize Laureate

Field
Medical Science and Medicinal Science
Achievement
Proposal of the concept of gene therapy and its clinical applications
Commemorative Lecture
Gene therapy, from primary immunodeficiencies to diversified indications
Nationality: Republic of France
Date of Birth: September 11, 1949
Academic Degrees:
1979 M.D. from Université Paris Descartes
1979 Ph.D. from Université Paris Jussieu
Professional Career:
1980-1981 Postdoctoral fellowship in Immunology at University College London
1981-1991 Group leader – Institut national de la santé et de la recherche médicale (INSERM) Unit 132, Hôpital Necker-Enfants malades, Paris
1984-1988 Tenured clinical position in the Pediatric Immunology Department, Hôpital Necker-Enfants malades
1988-2013 Professor of Pediatric Immunology (Université Paris Descartes)
1991-2013 Director of INSERM Unit 768 for “Développement Normal et Pathologique du Système Immunitaire (Normal and pathological development of the immune system),” Hôpital Necker-Enfants malades, Université Paris Descartes
1996-2012 Director of Pediatric Immunology Department, Hôpital Necker-Enfants malades
2006-present Professor at Institut Universitaire de France
2007-present Director of Institut Imagine (Institut des maladies génétiques), Hôpital Necker-Enfants malades, Université Paris Descartes, Inserm U1163
2014-present Professor at Collège de France (chaire de médecine expérimentale)
Affiliation:
Institut Imagine
24 Boulevard Montparnasse
785015 Paris, France
Major Publications:
  1. Stephan V, Wahn V, Le Deist F., Dirksen U, Broker B., Muller-Fleckenstein I, Horneff G. Schroten H., Fischer A, de Saint Basile G. Atypical X-linked severe combined immunodeficiency due to possible spontaneous reversion of the genetic defect in T cells. New Engl J Medecine 335(21):1563-1567, 1996
  2. Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, Gross F, Yvon E, Nusbaum P, Selz F, Hue C, Certain S, Casanova JL, Bousso P, Deist FL, Fischer A. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288(5466): 669-672, 2000.
  3. Hacein-Bey-Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, De Villartay JP, Thrasher AJ, Wulffraat N, Sorensen R, Dupuis-Girod S, Davies EG, Kuis W, Leiva L, Fischer A, Cavazzana-Calvo M. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med 346(16): 1185-1193, 2002.
  4. Hacein-Bey-Abina S, von Kalle C, Schmidt M, Le Deist F, Wulffraat N, McIntyre E, Radford I, Villeval JL, Fraser CC, Cavazzana-Calvo M, Fischer A. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 348(3): 255-256, 2003.
  5. Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A*, Cavazzana-Calvo M*. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302(5644): 415-419, 2003. * cosenior authors
  6. Hacein-Bey-Abina S, Hauer J, Lim A, Picard C, Wang GP, Berry CC, Martinache C, Rieux-Laucat F, Latour S, Belohradsky BH, Leiva L, Sorensen R, Debré M, Casanova JL, Blanche S, Durandy A, Bushman FD, Fischer A*, Cavazzana-Calvo M*. Efficacy of gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 363(4): 355-364, 2010. * cosenior authors
  7. Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Bleesing J, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, de Oliveira S, Fernandez KS, Guo D, Harris CE, Hopkins G, Lehmann LE, Lim A, London WB, van der Loo JC, Malani N, Male F, Malik P, Marinovic MA, McNicol AM, Moshous D, Neven B, Oleastro M, Picard C, Ritz J, Rivat C, Schambach A, Shaw KL, Sherman EA, Silberstein LE, Six E, Touzot, Tsytsykova A, Xu-Bayford J, Baum C, Bushman FD*, Fischer A*§, Kohn DB*, Filipovich AH*, Notarangelo LD*, Cavazzana M*, Williams DA*§, Thrasher AJ*. A modified gamma-retrovirus vector for X-linked severe combined immunodeficiency. News Engl J Med 371(15):1407-1417,2014* cosenior authors; § cocoresponding authors
Major Honors:
  • 1984 Halpern Prize
  • 1992 Prix Behring-Metchnikoff
  • 1994 Prix du Comité du Rayonnement français
  • 1998 Jung Prize for Medicine (Hamburg)
  • 2000 Prix Pierre Royer
  • 2000 NRJ Foundation – Institut de France – Award
  • 2001 Joint winner of the Louis-Jeantet Prize for Medicine
  • 2001 Novartis Prize for Clinical Immunology
  • 2003 A. Philipson Prize (Stockholm)
  • 2005 Honorary Degree of the University of Zurich
  • 2005 Descartes Prize (European Community)
  • 2008 INSERM Grand Prix
  • 2010 Officier de la Légion d'honneur
  • 2011 Senior advanced grant from ERC (European Research Council)
  • 2012 Avery Landsteiner prize
  • 2013 Grand prix Claude Bernard de la ville de Paris
  • 2013 Sanofi-Pasteur prize
  • 2014 Robert Koch prize
Memberships:
  • 2002 Member of the European Molecular Biology Organization
  • 2002 Member of the French Academy of Science
  • 2009 Member of the Academia Europea

(As of January 2015)

More about the Laureates

30 Years of Japan Prize

page top