The 1999 Japan Prize

• Field:
  Molecular Recognition and Dynamics in Bioscience
• Achievement:
  Elucidation of the three-dimensional structures of class I and class II human histocompatibility antigens and their bound peptides
• Lecture:
  The Role of Three-Dimensional Structures in Understanding MHC Restricated Antigen Presentation

Major Awards

1990	Louisa Gross Horwitz Prize, Columbia University
1992	William B. Coley Award for Distinguished Research in Fundamental Immunology sponsored by the Cancer Research Institute
1992	V.D. Mattia Award sponsored by the Roche Institute
1993	The Passano Foundation Award
1993	Emil von Behring Prize
1994	Gairdner Foundation International Award
1995	Doctorate Honoris Causa, The University of Leiden, The Netherlands
1995	Albert Lasker Basic Medical Research Award
1996	The Rose Payne Distinguished Scientist Award

Membership in Academic Institutions and Societies

	American Academy of Arts and Sciences Fellow
	American Association for the Advancement of Science
	American Chemical Society
	American Crystallographic Association
	American Philosophical Society Member
	American Society for Biochemistry and Molecular Biology
	American Society for Microbiology
	American Society for Virology
	Biophysical Society
	Juvenile Diabetes Foundation International
	National Academy of Sciences Fellow
	The Protein Society

Title

• John L. Loeb Professor of Biochemistry and Biophysics, Harvard University

Academic Degrees

1966	B.S. Tufts University
1971	Ph.D. Harvard University

Professional Career

1971-75	Assistant Professor, Harvard University
1975-79	Associate Professor, Harvard University
1979-98	Professor of Biochemistry and Biophysics, Harvard University
1980-92	Chairman, Committee on Higher Degrees in Biophysics, Harvard University
1990-Pres	Research Associate in Medicine, The Children's Hospital
1992-95	Chairman, Department of Molecular and Cellular Biology Harvard University
1995-Present	Affiliate, Department of Chemistry and Chemical Biology, Harvard University
1998-Present	John L. Loeb Professor of Biochemistry and Biophysics and Howard Hughes Medical Institute Investigator,Harvard University

Major Publications and Scientific Papers

• Bjorkman, P.J., Saper, M., Samraoui, B., Bennett, W., Strominger, J.L. and Wiley, D.C. Structure of the Human Class I Histocompatibility Antigen, HLA-A2, Nature 329, 506-512, 1987.
• Madden, D.R., Gorga, J.C., Strominger, J.L. and Wiley, D.C. The Structure of HLA-B27 Reveals Nonamer 'Self-Peptides' Bound in an Extended Conformation, Nature 353, 321-325, 1991.
• Brown, J.H., Jardetzky, T.S., Gorga, J.C., Stern, L.J., Urban, R.G., Strominger, J.L. and Wiley, D.C. The Three-Dimensional Structure of the Human Class II Histocompatibility Antigen HLA-DR1. Nature 364, 33-39, 1993.
• Stern, L.J., Brown, J.H., Jardetzky, T.S. and Wiley, D.C. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368, 215-221, 1994.
• Garboczi, D.N., Ghosh, P., Utz., U., Fan, Q.R., Biddison, W.E. and Wiley, D.C. Structure of the Complex between Human T Cell Receptor, Viral Peptide, and HLA-A2, Nature 384, 134-141, 1996.