Laureates of the Japan Prize

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Dr. Jack L. Strominger

1999 (15th) Japan Prize Laureate

Field
Molecular Recognition and Dynamics in Bioscience
Achievement
Elucidation of the three-dimensional structures of class I and class II human histocompatibility antigens and their bound peptides
Commemorative Lecture
MHC proteins and human diseases: A tale of recognition in two immune systems
Nationality: USA
Date of Birth: August 7 1925
Academic Degrees:
1947 A.B. Harvard University
1948 M.D. Yale University
Professional Career:
1955-58 Assistant Professor, Washington University School of Medicine
1958-60 Associate Professor, Washington University School of Medicine
1960-64 Professor, Washington University School of Medicine
1964-68 Professor, University of Wisconsin Medical School 1968- Professor of Biochemistry, Harvard University
1970-73 Chairman, Department of Biochemistry & Molecular Biology Harvard University
1983- Present Higgins Professor of Biochemistry, Harvard University Scientific member, Dana-Farber Cancer Institute, Harvard Medical School
Title: Higgins Professor of Biochmistry, Harvard University.
Major Publications and Scientific Papers:
  1. Turner, M.J., Cresswell, P., Parham. P., Strominger, J.L., Mann, D.L., and Sanderson, A.R. Purification and some properties of papain-solubilized histocompatibility antigens from a cultured human lymphoblastoid line, RPMI 4265. J. Biol. Chem. 250: 4512-4519, 1975.
  2. Orr, H.T., Lopez de Castro, J.A., Lancet, D. and Strominger, J.L. Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies. Biochemistry 18: 5711-5719, 1979.
  3. Silver, M.L., Guo, H.-C., Strominger, J.L. and Wiley, D.C. Atomic structure of a human MHC molecule presenting an influenza virus peptide. Nature 360: 367-369, 1992.
  4. Gorga, J., Horejsi, V., Johnson, D., Raghupathy, R. and Strominger, J.L. Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line. J. Biol. Chem. 262: 16087-16094, 1987.
  5. Gorga, J.C., Brown, J.H., Jardetzky, T., Wiley, D.C., and Strominger, J.L. Crystallization of HLA-DR antigens. Res. Immunol. 142: 401-407, 1991.
Major Awards:
  • John J. Abel Award in Pharmacology (1960)
  • Paul-Lewis Laboratories Award in Enzyme Chemistry (1962)
  • National Academy of Sciences Award in Microbiology in honor of Selman Waxman (1968)
  • Rose Payne Award, American Society for Histocompatibility & Immunogenetics (1986)
  • Hoescht-Roussel Award, American Society for Microbiology Pasteur Medal in Gold (1990)
  • Albert Lasker Basic Medical Research Award Louisa Gross Horwitz Prize, Columbia University (1995)
Membership in Academic Institutions and Societies:
  • American Academy of Arts and Sciences (elected 1968)
  • National Academy of Sciences of the USA (elected 1970)
  • American Philosophical Society (elected 1994)
  • American Society of Biochemistry and Molecular Biology
  • American Association for Advancement of Sciences
  • American Association of Immunologists
  • 7American Society of Microbiologists
  • American Society of Pharmacology & Experimental Therapeutics
  • American Chemical Society

( At the time of receipt of the Prize )

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