| Nationality: |
Japan |
| Date of Birth: |
November 14 1933 |
| Academic Degrees: |
| 1957 |
B. A., Tohoku University Faculty of Agriculture, Sendai, Japan |
| 1966 |
Ph.D. in Biochemistry, Tohoku University |
| Professional Career: |
| 1957-1966 |
Research Fellow, Sankyo Co., Ltd., Tokyo, Japan |
| 1966-1968 |
Research Associate, Department of Molecular Biology (Prof. Dr. B.L. Horecker),
Albert Einstein College of Medicine, New York, USA |
| 1968-1969 |
Research Fellow, Sankyo Co., Ltd., Tokyo, Japan |
| 1969-1978 |
Senior Research Fellow, Sankyo, Co., Ltd. |
| 1979-1986 |
Associate Professor, Faculty of Agriculture,
Tokyo University of Agriculture and Technology,
Fuchu, Tokyo, Japan |
| 1986-1997 |
Professor, Faculty of Agriculture, Tokyo University of Agriculture and Technology |
| 1997-present |
Director, Biopharm Research Laboratories, Inc., Tokyo, Japan |
| Title: |
Director, Biopharm Research Laboratories, Inc., Tokyo, Japan |
| Major Publications: |
- Endo A, Kuroda M, Tsujita Y. ML-236A, ML-236B, and ML236-C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J Antibiot 1976;29:1346-1348.
- Endo A, Kuroda M, Tanzawa K. Competitive inhibition of 3-hydroxy-3-metgylglutaryl coenzyme A reductase by ML-236A and ML 236B fungal metabolites, having hypocholesterolemic activity. FEBS Lett 1976;72:323-326.
- Endo A, Tsujita T, Kuroda M, Tanzawa K. Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3methylglutaryl-coenzyme A reductase. Eur J Biochem 1977;77:31-36.
- Brown MS, Faust JR, Goldstein JL, Kaneko I, Endo A. Induction of 3-hydroxy-3methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase. J Biol Chem 1978;253:1121-1128.
- Tsujita Y, Kuroda M, Tanzawa K,Kitano N, Endo A. Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Atherosclerosis 1979; 32:307-313.
- Endo A, Tsujita Y, Kuroda M, Tanzawa K. Effects of ML-236B on cholesterol metabolism in mice and rats: lack of hypocholesterolemic activity in normal animals. Biochim Biophys Acta 1979; 575:266-276.
- Yamamoto A, Sudo H, Endo A. Therapeutic effects of ML 236B in primary hypercholesterolemia. Atherosclerosis 1980; 35:259-266.
- Endo A. The discovery and development of HMG-CoA reductase inhibitors. J Lipid Res 1992; 33:1569-1582.
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| Major Honors: |
- Young Investigator Award in agricultural chemistry (Japan) (1966)
- Heinrich Wieland Prize for the discovery of the HMG-CoA reductase inhibitors (West Germany) (1987)
- Toray Science and Technology Prize (Japan) (1988)
- Warren Alpert Foundation Prize (Harvard Medical School, USA) (2000)
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