Laureates of the Japan Prize

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Dr. Toshio Hirano

2011 (27th) Japan Prize Laureate

Field
Bioscience and Medical Science
Achievement
Discovery of interleukin-6 and its application in treating diseases
Nationality: Japan
Date of Birth: April 17 1947
Academic Degrees:
1972 Graduate School of Medicine, Osaka University
Professional Career:
1973 Studied abroad at National Institutes of Health, United States
1978 Osaka Prefectural Habikino Hospital
1980 Assistant Professor of School of Medicine, Kumamoto University
1984 Assistant Professor at Osaka University,
Institute for Molecular and Cellular Biology
1989

Professor of Medicine, Osaka University

2001

Group Director of Riken Research Center for Allergy and Immunology

2002

Professor of Graduate School of Frontier Biosciences, Osaka University

2004

Dean of Graduate School of Frontier Biosciences, Osaka University

2007 Professor of WPI Immunology Frontier Research Center, Osaka University
2008 Dean of Graduate School of Medicine, Osaka University
Title: Professor, Osaka University
Major Publications:
  1. Hirano T, Teranishi T, Toba H, Sakaguchi N, Fukukawa T, Tsuyuguchi I. Human helper T cell factor(s) (ThF). I. Partial purification and characterization. J Immunol. 1981; 126: 517-522.
  2. Teranishi T, Hirano T, Arima, N and Onoue K. Human helper Tcell factor(s) (ThF). II. Induction of IgG production in B lymphoblastoid cell lines and identification of T cell replacing factor-(TRF) like factor(s). J. Immunol. 1982; 128:1903-1908.
  3. Hirano T, Yasukawa K, Harada T, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, Tsunasawa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986; 324: 73-76.
  4. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 1988; 332: 83-85.
  5. Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T. Cloning and expression of human interleukin 6 (BSF-2/IFNb2) receptor. Science 1988; 241: 825-828.
  6. Hirano T, Matsuda T, Turner M, Miyasaka N, Buchan G, Tang B, Sato K, Shimizu M, Maini R, Feldmann M, Kishimoto T. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol. 1988; 18: 1797-1801.
  7. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989; 58: 573-581.
  8. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990; 63: 1149-1157.
  9. Nakajima K, Yamanaka Y, Nakae K, Kojima H, Kiuchi N, Ichiba M, Kitaoka T, Fukada T, Hibi M and Hirano T. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J. 1996; 15:3651-3658.
  10. Fukada T, Hibi M, Yamanaka Y, Takahashi-Tezuka M, Fujitani Y, Yamaguchi T, Nakajima K, Hirano T. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity. 1996; 5: 449-460.
  11. Ohtani T, Ishihara K, Atsumi T, Nishida K, Kaneko Y, Miyata T, Itoh S, Narimatsu M, Maeda H, Fukada T, Itoh M, Okano H, Hibi M, Hirano T. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity. 2000; 12: 95-105.
  12. Atsumi T, Ishihara K, Kamimura D, Ikushima H, Ohtani T, Hirota S, Kobayashi H, Park S-J, Saeki Y, Kitamura Y, and Hirano T. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. 2002; J. Exp. Med. 196:979-990.
  13. Sawa S, Kamimura D, Jin G-H, Morikawa H, Kamon H, Nishihara M, Ishihara K, Murakami M, and Hirano T. Autoimmune arthritis associated with mutated IL-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J. Exp. Med. 2006; 203:1459-1470.
  14. Ogura H, Murakami M, Okuyama Y, Tsuruoka M, Kitabayashi C, Kanamoto M, Nishihara M, Iwakura Y and Hirano T. Interleukin-17 promotes autoimmunity by triggering a positive feedback loop via interleukin-6 induction. Immunity 2008; 29:628-636.
  15. Hirano T. Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir. 2010; Proc. Jpn. Acad., Ser. B. 86: 717-730.
Major Honors:
  • Erwin von Bälz Prize (1986)
  • CIBA-GEIGY Rheumatism Prize (1990)
  • Sandoz Prize for Immunology (1992)
  • Osaka Science Prize (1997)
  • Mochida Memorial Prize (1998)
  • ISI Citation Laureate Award, 1981-1988 (2000)
  • The Fujihara Prize (2004)
  • Medical Award of the Japan Medical Association (2005)
  • The Emperor's Purple Ribbon Medal (2006)
  • The Crafoord Prize from the Royal Swedish Academy of Sciences (along with Dr. Tadamitsu Kishimoto)(2009)
  • Suita city award (2009)
  • Osaka City Mayoral Special Award (2010)
Membership:
  • President of Japanese Society for Immunology (2005-2006)
  • Board Member of Japanese Society for Immunology
  • Board Member of International Society for Zinc Biology
  • Member of the American Association of Immunologists
  • Member of Japanese Cancer Association
  • Member of the Japanese Biochemical Society
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