Laureates of the Japan Prize

photo

Dr. Tadamitsu Kishimoto

2011 (27th) Japan Prize Laureate

Field
Bioscience and Medical Science
Achievement
Discovery of interleukin-6 and its application in treating diseases
Nationality: Japan
Date of Birth: May 7 1939
Academic Degrees:
1964 Bachelor of Medicine, Osaka University
1969 Ph.D. in Medicine, Osaka University
Professional Career:
1969 Assistant researcher of Biochemistry in Faculty of Dental Science, Kyushu University
1970 Research fellow and Visiting Assistant Professor, Johns Hopkins University, U.S.A
1974 Assistant Professor of Medicine, Osaka University
1979 Professor of Medicine, Osaka University
1983 Professor at Institute for Molecular and Cellular Biology, Osaka University
1991 Professor of Medicine, Osaka University
1995 Dean of Faculty of Medicine, Osaka University
1997 President of Osaka University
2004 Member of Council for Science and Technology Policy
2006 Endowed Chair Professor at School of Frontier Biosciences, Osaka University
2007 President, Senri Life Science Foundation
Title: Emeritus Professor, Osaka University
Major Publications:
  1. Hirano T, Yasukawa K, Harada T, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, Tsunasawa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986; 324: 73-76.
  2. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 1988; 332:83-85.
  3. Yamasaki K, Taga T, Hirano Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T. Cloning and expression of human interleukin 6 (BSF-2/IFNb2) receptor. Science 1988; 241: 825-828.
  4. Hirano T, Matsuda T, Turner M, Miyasaka N, Buchan G, Tang B, Sato K, Shimizu M, Maini R, Feldmann M, Kishimoto T. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol. 1988; 18: 1797-1801.
  5. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989; 58: 573-581.
  6. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990; 63: 1149-1157.
  7. Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor: a paradigm for cytokines. Science 1992; 258: 593-597.
  8. Nishimoto N, Yoshizaki K, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Hashimoto J, Azuma J, Kishimoto T. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 antibody: a multicenter double-blind, placebo-controlled trial. Arthritis Rheum 2004; 50: 1761-1769.
  9. Nishimoto N, Kishimoto T. Interleukin 6: from bench to bedside. Nat Clin Pract Rheumatol. 2006; 2: 619-626.
  10. Yokota S, Imagawa T, Mori M, Miyamae T, Aihara Y, Takei S, Iwata N, Umebayashi H, Murata T, Miyoshi M, Tomiita M, Nishimoto N, Kishimoto T. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet 2008; 371: 998-1006.
Major Honors:
  • Behring-Kitasato Prize (1982)
  • Osaka Science Prize (1983)
  • Erwin von Bälz Prize (1986)
  • Takeda Prize, Asahi Prize (1988)
  • Prize of the Japanese Medical Association, Person of Cultural Merits JAPAN (1990)
  • Scientific Achievement Award from the International Association of Allergology and Clinical Immunology (1991)
  • Imperial Prize from the Japan Academy Sandoz Prize for Immunology from the International Union of Immunological Society (along with Dr. Toshio Hirano) (1992)
  • Member, the Japan Academy (1995)
  • The Avery-Landsteiner Prize from the German Immunology Society (1996)
  • The Order of Culture from Emperor (1998)
  • The Donald Seldin Award from the International Society of Nephrology (1999)
  • ISI Citation Laureate Award, 1981-1988 (2000)
  • Robert Koch Gold Medal from the Koch Foundation of Germany (2003)
  • Honorary Life Time Achievement Awards (International Cytokine Society) (2006)
  • The Crafoord Prize from the Royal Swedish Academy of Sciences (along with Dr. Toshio Hirano) (2009)
  • President's Award from the Clinical immunology society of United States (2010)
Membership:
  • Foreign Associate of the US National Academy of Sciences (1991)
  • President of the Japanese Society for Immunology (1991)
  • President of the International Congress of Immunopharmacology (1991)
  • Honorary member of The American Association of Immunologists (1992)
  • President of the International Society for Interferon and Cytokine Research (1994)
  • Member of the Japan Academy (1995)
  • President of the Japanese Society for Immunology (1997)
  • President of the Japanese Society of Allergology (1997)
  • President of the Japan Society for Clinical Immunology (1997)
  • Honorary member of the American Society of Hematology (1997)
  • Foreign member of the Institute of Medicine of the US National Academy of Sciences (1997)
  • Vice President of the Japanese Medical Association (2002)
  • Member, Deutsche Akademie der Naturforscher Leopoldina (2005)
  • President of the 27th General Assembly of the Japanese Medical Association (2007)
  • President of the 14th International Congress of Immunology (2010)

( At the time of receipt of the Prize )

Google
Japan Prize Site Search
Internet Search

More about the Laureates

30 Years of Japan Prize

page top