Laureates of the Japan Prize


Dr. Bruce N. Ames

1997 (13th) Japan Prize Laureate

Biotechnology in Medicine
Contribution to establishment of fundamental concept on causes of cancer
Commemorative Lecture
Functional principles and neural mechanisms of the brain studied in the cerebellum
Nationality: USA
Date of Birth: December 16, 1928
Academic Degrees:
1950 Cornell University, B.A.
1953 California Institute of Technology, Ph. D.
Biochemistry Major with Prof. H. K. Mitchell;
Chemistry and Genetics Minors
Professional Career:
1953-54 Postdoctoral Fellow (U.S.P.H.S.) at National Institutes of Health with Dr. B. L. Horecker
1954-60 Biochemist at the National Institutes of Health
1961 Sabbatical year as N.S.F. Senior Fellow in laboratories of F.H. C.Crick in Cambridge, England, and F. Jacob in Paris, France
1962-67 Chief, Section of Microbial Genetics, Laboratory of Molecular Biology, N.I.A.M.D., National Institutes of Health
1968-Present Professor, Division of Biochemistry and Molecular Biology, University of California, Berkeley
1983-89 Chairman, Division of Biochemistry and Molecualr Biology, University of California, Berkeley
1979-Present Director, National Institute of Environmental Health Sciences Center, University of California, Berkeley
Title: Professor of Biochemistry and Molecular Biology, University of California, Berkeley
Major Publications and Scientific Papers:
  1. Martin, R.G. and Ames, B.N. A method for determining the sedimentation behavior of enzymes: Application to protein mixtures. J.Biol. Chem. 236:1372-1379, 1961.
  2. Ames, B.N. and Whitefield, Jr., H.J. Frameshift mutagenesis in Salmonella. Cold Spring Harbor Symposia on Quantitative Biology, 31:221-225, 1966.
  3. McCann, J., Spingarn, N.E., Kobori, J. and Ames, B.N. Detection of carcinogens as mutagens: Bacterial tester strains with R factor plasmids. Proc. Natl. Acad. Sci. USA, 72:979-988, 1975.
  4. McCann, J., Choi, E., Yamasaki, E. and Ames, B.N. Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proc. Natl. Acad. Sci. USA, 72: 5135-5139,1975.
  5. Maron, D.M. and Ames, B.N. Revised methods for the Salmonella mutagenicity test. Mutation Res., 113:173-215, 1983.
  6. Ames, B.N. and Gold, L.S. Chemical Carcinogenesis: Too Many Rodent Carcinogens. Proc. Natl. Acad. Sci. USA, 87:7772-7776, 1990.
  7. Ames, B.N., Profet, M. and Gold, L.S. Dietary Pesticides (99.99% All Natural). Proc. Natl. Acad. Sci. USA, 87:7777-7781, 1990.
  8. Ames, B.N., Profet, M. and Gold, L.S. Nature's Chemicals and Synthetic Chemicals: Comparative Toxicology. Proc. Natl. Acad. Sci. USA, 87:7782-7786, 1990.
  9. Ames, B.N., Shigenaga, M.K. and Hagen, T.M. Oxidants, Antioxidants, and the Degenerative Diseases of Aging. Proc. Natl. Acad. Sci. USA, 90:7915-7922, 1993.
  10. Shigenaga, M.K., Hagen, T.M. and Ames, B.N. Oxidative Damage and Mitochondrial Decay in Aging. Proc. Natl. Acad. Sci. USA, 91:10771-10778, 1994.
  11. Gee, P., Maron, D.M. and Ames, B.N. Detection and classification of mutagens: A set of base-specific Salmonella tester strains. Proc. Natl. Acad. Sci. USA, 91:11606-11610, 1994.
  12. Ames, B.N., Cold, L.S. and Willett, W.C. The causes and prevention of cancer. Proc. Natl. Acad. Sci. USA, 92: 5258-5265, 1995.
Major Awards:
  • Eli Lilly Award of the American Chemical Society (1964)
  • Arthur Flemming Award (as Outstanding Young Government Employee) (1966)
  • Lewis Rosenstiel Award (1976)
  • FASEB/3M Award for Research in Life Sciences (1976)
  • E.R.D.A. Distinguished Associate Award (1976)
  • Environmental Mutagen Society Award (1977)
  • Cal. Tech. Distinguished Alumni Award (1977)
  • Simon Shubitz Cancer Prize (1978)
  • Felix Wankel Research Award (1978)
  • John Scott Medal (1979)
  • Bolton L. Corson Medal (1980)
  • New Brunswick Lectureship Award of A.S.M. (1980)
  • Wadsworth Award (1981)
  • Charles S. Mott Prize, General Motors Cancer Research Foundation (1983)
  • Gairdner Foundation Award (Canada) (1983)
  • Tyler Prize for Environmental Achievement (1985)
  • Spencer Award (American Chemical Society) (1986)
  • Gold Medal , American Institute of Chemists (1991)
  • Glenn Foundation Award, Gerontological Society of America (1992)
  • Lovelace Award for Excellence in Environmental Health Research (1995)
  • Honda Prize, Honda Foundation (Japan) (1996)
Major Honors:
  • American Academy of Arts and Sciences (1970)
  • National Academy of Sciences (1972)
  • Fellow of the American Association for the Advancement of Science (1980)
  • Honorary Member of Japanese Cancer Association (1987)
  • Foreign Member of the Royal Swedish Academy of Sciences (1989)
Membership in Academic Institutions and Societies:
  • American Chemical Society
  • American Society of Biological Chemists
  • Genetics Society of America
  • American Society for Microbiology
  • Environmental Mutagen Society
  • American Association for Cancer Research
  • Society of Toxicology
  • Federation of American Scientists

( At the time of receipt of the Prize )

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