Laureates of the Japan Prize


Dr. Takashi Sugimura

1997 (13th) Japan Prize Laureate

Biotechnology in Medicine
Contribution to establishment of fundamental concept on causes of cancer
Commemorative Lecture
Establishment of the Basic Concept that Cancer is a Disease of DNA
Nationality: Japan
Date of Birth: April 20, 1926
Academic Degrees:
1949 Graduated from Faculty of Medicine, The University of Tokyo, The degree of M.D.
1957 The degree of Doctor of Medical Science from Departmentof Biochemistry, Faculty of Medicne, The University of Tokyo
Professional Career:

Chief, Biochemistry Division, National Cancer Center Research Institute, Tokyo

1970-85 Professor, Institue of Medical Science, The University of Tokyo
1972-74 Deputy Director, National Cancer Center Research Institute,Tokyo
1974-84 Director, National Cancer Center Research Institute Tokyo
1984-91 President, National Cancer Center, Tokyo
1992-Present President Emeritus, National Cancer Center, Tokyo
1992-94 Advisor, Ministry of Health and Welfare
1994-Present President, Toho University
Title: President Emer itus of National Cancer Center and President of Toho University
Major Scientific Papers:
  1. Nakahara, W., Fukuoka, F. and Sugimura, T. Carcinogenic action of 4-nitroquinoline 1-oxide. Gann, 48:129-137, 1957.
  2. Sugimura, T., Nagao, M. and Okada, K. Carcinogenic action of N-methyl-N'-nitro-N-nitrosoguanidine. Nature, 210: 962-963, 1966.
  3. Sugimura, T., Okabe, K. and Nagao, M. The metabolism of 4-nitroquinoline 1-oxide, a carcinogen. III: An enzyme catalyzing the conversion of 4-nitroquinoline 1-oxide to 4-hydroxyaminoquinoline 1-oxide in rat liver and hepatomas. Cancer Res., 26: 1717-1721, 1966.
  4. Matsushima, T., Kobuna, I. and Sugimura, T. In vivo interaction of 4-nitroquinoline 1-oxide and its derivatives with DNA. Nature, 216: 508, 1967.
  5. Sugimura, T., and Fujimura, S. Tumor production in glandular stomach of rat by N-methyl-N'-nitro-N-nitrosoguanidine. Nature, 216:943-944, 1967.
  6. Sugimura, T., Otake, H. and Matsushima, T. Single strand scissions of DNA caused by a carcinogen, 4-hydroxyaminoquinoline 1-oxide. Nature, 218:392, 1968.
  7. Sugimura, T., Nagao, M., Kawachi, T., Honda, M., Yahagi, T., Seino, Y., Sato, S., Matsukura, N., Matsushima, T., Shirai, A., Sawamura, M. and Matsumoto, H. Mutagen-carcinogens in food, with special reference to highly mutagenic pyrolytic products in broiled foods. In : H.H. Hiatt, J.D. Watson, and J.A. Winsten (eds), Origins of Human Cancer, pp. 1561-1577, Cold Spring Harbor, NY:Cold Spring Harbor Laboratory, 1977.
  8. Sugimura, T. Studies on environmental chemical carcinogenesis in Japan. Science, 233: 312-318, 1986.
  9. Sugimura, T. Multiple carcinogenesis: A 1992 perspective. Science, 258:603-607, 1992.
  10. Sugimura, T., Nagao, M. and Wakabayashi, K. Heterocyclic amines in cooked foods: Candidates for causation of common cancers. J. Natl. Cancer Inst., 86:2-4, 1994.
  11. Kakiuchi, H., Watanabe, M., Ushijima, T., Toyota, M., Imai, K., Weisburger, J.H., Sugimura, T. and Nagao, M. Specific 5'-GGGA-3' -5'-GAA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine. Proc. Natl. Acad. Sci. USA, 92: 910-914, 1995.
  12. Toyota, M., Ushijima, T., Weisburger, J.H., Hosoya, Y., Canzian, F., Rivenson, A., Imai, K., Sugimura, T. and Nagao, M. Microsatellite instability and loss of heterozygosity on chromosome 10 in rat mammary tumors induced by 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine. Molecular Carcinogenesis, 15: 176-182, 1996.
Major Awards:
  • Prize of Princess Takamatsu Cancer Research Fund (Experimental Studies on Stomach Cancer) (1969)
  • Prize of Takeda Medical Foundation (Studies on Gastric Cancer and Cancr Biochemistry) (1974)
  • Prize of Fujihara Foundation (Studies on poly (ADP-Ribose)) (1975)
  • Japan Academy Prize and Imperial Prize (Studies on Experimental Stomach Cancer) (1976)
  • Fogarty Scholar in Residence, National Institutes of Health, USA (1977)
  • The Outstanding Work Award of the Environmental Mutagen Society of the United States (The Relation between Mutagens and Carcinogens and the Identification of Environmental Mutagens) (1978)
  • The Order of Cultural Merits of the Japanese Government 1981 The Ernst W. Bertner Memorial Award (1978)
  • The Charles S. Mott Prize of General Motors Cancer Research Foundation (1981)
  • The Tomizo Yoshida Prize, Japanese Cancer Association (1992)
  • The 1st Award of the Environmental Mutagen Society of Japan (1994)
Major Honors:
  • Honorary Member of the American Association for Cancer Research (1980)
  • Foreign Associate of the National Academy of Sciences, USA (1982)
  • Member of the Japan Academy (1982)
  • Honorary Member of the Pharmaceutical Society of Japan (1986)
  • Honorary Member of the Environmental Mutagen Society of Japan (1987)
  • Foreign Member of the Royal Netherlands Academy of Arts and Sciences (Division for Sciences) (1987)
  • Foreign Member of the Royal Swedish Academy of Sciences (Class for Medical Sciences) (1987)
  • Honorary Member of the American Society for Biochemistry and Molecular Biology (1988)
  • Honorary Member of Japanese Biochemical Society (1990)
  • Honorary Member of the Korean Cancer Association (1992)
  • Honorary Degree of Doctor of Science of the Thomas Jefferson University (1994)
  • Foreign Associate of the Institute of Medicine, National Academy of Sciences, USA (1994)
  • Honorary Member of Japanese Cancer Association (1994)
  • Japan Society of Clinical Biochemistry and Metabolism
  • Japan Pancreas Society
  • Japan Society of Cancer Epidemiology
  • Japan Society for Cancer Therapy
  • Japan Society of Gene Therapy
  • Japanese Association for Animal Cell Technology
  • Japanese Biochemical Society
  • Japanese Cancer Association
  • Japanese Environmental Mutagen Society
  • Japanese Society of Nutrition and Food Science
  • Molecular Biology Society of Japan

( At the time of receipt of the Prize )

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