Japan Prize Laureates

Laureates of the Japan Prize

Dr. Takashi Sugimura

Dr. Takashi Sugimura

  • Nationality:
  • Date of Birth:
    20 April 1926

Outline of Achievements

Outline of Achievements

The 1997 Japan Prize

Major Awards

1969 Prize of Princess Takamatsu Cancer Research Fund (Experimental Studies on Stomach Cancer)
1974 Prize of Takeda Medical Foundation (Studies on Gastric Cancer and Cancr Biochemistry)
1975 Prize of Fujihara Foundation (Studies on poly (ADP-Ribose))
1976 Japan Academy Prize and Imperial Prize (Studies on Experimental Stomach Cancer)
1977 Fogarty Scholar in Residence, National Institutes of Health, USA
1978 The Outstanding Work Award of the Environmental Mutagen Society of the United States (The Relation between Mutagens and Carcinogens and the Identification of Environmental Mutagens)
1978 The Order of Cultural Merits of the Japanese Government 1981 The Ernst W. Bertner Memorial Award
1981 The Charles S. Mott Prize of General Motors Cancer Research Foundation
1992 The Tomizo Yoshida Prize, Japanese Cancer Association
1994 The 1st Award of the Environmental Mutagen Society of Japan

Major Honors

1980 Honorary Member of the American Association for Cancer Research
1982 Foreign Associate of the National Academy of Sciences, USA
1982 Member of the Japan Academy
1986 Honorary Member of the Pharmaceutical Society of Japan
1987 Honorary Member of the Environmental Mutagen Society of Japan
1987 Foreign Member of the Royal Netherlands Academy of Arts and Sciences (Division for Sciences)
1987 Foreign Member of the Royal Swedish Academy of Sciences (Class for Medical Sciences)
1988 Honorary Member of the American Society for Biochemistry and Molecular Biology
1990 Honorary Member of Japanese Biochemical Society
1992 Honorary Member of the Korean Cancer Association
1994 Honorary Degree of Doctor of Science of the Thomas Jefferson University
1994 Foreign Associate of the Institute of Medicine, National Academy of Sciences, USA
1994 Honorary Member of Japanese Cancer Association


Japan Society of Clinical Biochemistry and Metabolism
Japan Pancreas Society
Japan Society of Cancer Epidemiology
Japan Society for Cancer Therapy
Japan Society of Gene Therapy
Japanese Association for Animal Cell Technology
Japanese Biochemical Society
Japanese Cancer Association
Japanese Environmental Mutagen Society
Japanese Society of Nutrition and Food Science
Molecular Biology Society of Japan

Academic Degrees

1949 Graduated from Faculty of Medicine, The University of Tokyo, The degree of M.D.
1957 The degree of Doctor of Medical Science from Departmentof Biochemistry, Faculty of Medicne, The University of Tokyo

Professional Career

1962-72 Chief, Biochemistry Division, National Cancer Center Research Institute, Tokyo
1970-85 Professor, Institue of Medical Science, The University of Tokyo
1972-74 Deputy Director, National Cancer Center Research Institute,Tokyo
1974-84 Director, National Cancer Center Research Institute Tokyo
1984-91 President, National Cancer Center, Tokyo
1992-Present President Emeritus, National Cancer Center, Tokyo
1992-94 Advisor, Ministry of Health and Welfare
1994-Present President, Toho University


  • President Emer itus of National Cancer Center and President of Toho University

Major Scientific Papers

  • Nakahara, W., Fukuoka, F. and Sugimura, T. Carcinogenic action of 4-nitroquinoline 1-oxide. Gann, 48:129-137, 1957.
  • Sugimura, T., Nagao, M. and Okada, K. Carcinogenic action of N-methyl-N'-nitro-N-nitrosoguanidine. Nature, 210: 962-963, 1966.
  • Sugimura, T., Okabe, K. and Nagao, M. The metabolism of 4-nitroquinoline 1-oxide, a carcinogen. III: An enzyme catalyzing the conversion of 4-nitroquinoline 1-oxide to 4-hydroxyaminoquinoline 1-oxide in rat liver and hepatomas. Cancer Res., 26: 1717-1721, 1966.
  • Matsushima, T., Kobuna, I. and Sugimura, T. In vivo interaction of 4-nitroquinoline 1-oxide and its derivatives with DNA. Nature, 216: 508, 1967.
  • Sugimura, T., and Fujimura, S. Tumor production in glandular stomach of rat by N-methyl-N'-nitro-N-nitrosoguanidine. Nature, 216:943-944, 1967.
  • Sugimura, T., Otake, H. and Matsushima, T. Single strand scissions of DNA caused by a carcinogen, 4-hydroxyaminoquinoline 1-oxide. Nature, 218:392, 1968.
  • Sugimura, T., Nagao, M., Kawachi, T., Honda, M., Yahagi, T., Seino, Y., Sato, S., Matsukura, N., Matsushima, T., Shirai, A., Sawamura, M. and Matsumoto, H. Mutagen-carcinogens in food, with special reference to highly mutagenic pyrolytic products in broiled foods. In : H.H. Hiatt, J.D. Watson, and J.A. Winsten (eds), Origins of Human Cancer, pp. 1561-1577, Cold Spring Harbor, NY:Cold Spring Harbor Laboratory, 1977.
  • Sugimura, T. Studies on environmental chemical carcinogenesis in Japan. Science, 233: 312-318, 1986.
  • Sugimura, T. Multiple carcinogenesis: A 1992 perspective. Science, 258:603-607, 1992.
  • Sugimura, T., Nagao, M. and Wakabayashi, K. Heterocyclic amines in cooked foods: Candidates for causation of common cancers. J. Natl. Cancer Inst., 86:2-4, 1994.
  • Kakiuchi, H., Watanabe, M., Ushijima, T., Toyota, M., Imai, K., Weisburger, J.H., Sugimura, T. and Nagao, M. Specific 5'-GGGA-3' -5'-GAA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine. Proc. Natl. Acad. Sci. USA, 92: 910-914, 1995.
  • Toyota, M., Ushijima, T., Weisburger, J.H., Hosoya, Y., Canzian, F., Rivenson, A., Imai, K., Sugimura, T. and Nagao, M. Microsatellite instability and loss of heterozygosity on chromosome 10 in rat mammary tumors induced by 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine. Molecular Carcinogenesis, 15: 176-182, 1996.
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