Laureates of the Japan Prize


Dr. Don C. Wiley

1999 (15th) Japan Prize Laureate

Molecular Recognition and Dynamics in Bioscience
Elucidation of the three-dimensional structures of class I and class II human histocompatibility antigens and their bound peptides
Commemorative Lecture
The Role of Three-Dimensional Structures in Understanding MHC Restricated Antigen Presentation
Nationality: USA
Date of Birth: 21 October 1944
Academic Degrees:
1966 B.S. Tufts University
1971 Ph.D. Harvard University
Professional Career:
1971-75 Assistant Professor, Harvard University
1975-79 Associate Professor, Harvard University
1979-98 Professor of Biochemistry and Biophysics, Harvard University
1980-92 Chairman, Committee on Higher Degrees in Biophysics, Harvard University
1990-Pres Research Associate in Medicine, The Children's Hospital
1992-95 Chairman, Department of Molecular and Cellular Biology Harvard University
1995-Present Affiliate, Department of Chemistry and Chemical Biology, Harvard University
1998-Present John L. Loeb Professor of Biochemistry and Biophysics and Howard Hughes Medical Institute Investigator,Harvard University
Title: John L. Loeb Professor of Biochemistry and Biophysics, Harvard University
Major Publications and Scientific Papers:
  1. Bjorkman, P.J., Saper, M., Samraoui, B., Bennett, W., Strominger, J.L. and Wiley, D.C. Structure of the Human Class I Histocompatibility Antigen, HLA-A2, Nature 329, 506-512, 1987.
  2. Madden, D.R., Gorga, J.C., Strominger, J.L. and Wiley, D.C. The Structure of HLA-B27 Reveals Nonamer 'Self-Peptides' Bound in an Extended Conformation, Nature 353, 321-325, 1991.
  3. Brown, J.H., Jardetzky, T.S., Gorga, J.C., Stern, L.J., Urban, R.G., Strominger, J.L. and Wiley, D.C. The Three-Dimensional Structure of the Human Class II Histocompatibility Antigen HLA-DR1. Nature 364, 33-39, 1993.
  4. Stern, L.J., Brown, J.H., Jardetzky, T.S. and Wiley, D.C. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368, 215-221, 1994.
  5. Garboczi, D.N., Ghosh, P., Utz., U., Fan, Q.R., Biddison, W.E. and Wiley, D.C. Structure of the Complex between Human T Cell Receptor, Viral Peptide, and HLA-A2, Nature 384, 134-141, 1996.
Major Awards:
  • Louisa Gross Horwitz Prize, Columbia University (1990)
  • William B. Coley Award for Distinguished Research in Fundamental Immunology sponsored by the Cancer Research Institute V.D. Mattia Award sponsored by the Roche Institute (1992)
  • The Passano Foundation Award Emil von Behring Prize (1993)
  • Gairdner Foundation International Award (1994)
  • Doctorate Honoris Causa, The University of Leiden, The Netherlands Albert Lasker Basic Medical Research Award (1995)
  • The Rose Payne Distinguished Scientist Award (1996)
Membership in Academic Institutions and Societies:
  • American Academy of Arts and Sciences Fellow
  • American Association for the Advancement of Science
  • American Chemical Society
  • American Crystallographic Association
  • American Philosophical Society Member
  • American Society for Biochemistry and Molecular Biology
  • American Society for Microbiology
  • American Society for Virology
  • Biophysical Society
  • Juvenile Diabetes Foundation International
  • National Academy of Sciences Fellow
  • The Protein Society

( At the time of receipt of the Prize )

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