The 1999 Japan Prize

• Field:
  Molecular Recognition and Dynamics in Bioscience
• Achievement:
  Elucidation of the three-dimensional structures of class I and class II human histocompatibility antigens and their bound peptides
• Lecture:
  MHC proteins and human diseases: A tale of recognition in two immune systems

Major Awards

1960	John J. Abel Award in Pharmacology
1962	Paul-Lewis Laboratories Award in Enzyme Chemistry
1968	National Academy of Sciences Award in Microbiology in honor of Selman Waxman
1986	Rose Payne Award, American Society for Histocompatibility & Immunogenetics
1990	Hoescht-Roussel Award, American Society for Microbiology Pasteur Medal in Gold
1995	Albert Lasker Basic Medical Research Award Louisa Gross Horwitz Prize, Columbia University

Membership in Academic Institutions and Societies

	American Academy of Arts and Sciences (elected 1968)
	National Academy of Sciences of the USA (elected 1970)
	American Philosophical Society (elected 1994)
	American Society of Biochemistry and Molecular Biology
	American Association for Advancement of Sciences
	American Association of Immunologists
	7American Society of Microbiologists
	American Society of Pharmacology & Experimental Therapeutics
	American Chemical Society

Academic Degrees

1947	A.B. Harvard University
1948	M.D. Yale University

Professional Career

1955-58	Assistant Professor, Washington University School of Medicine
1958-60	Associate Professor, Washington University School of Medicine
1960-64	Professor, Washington University School of Medicine
1964-68	Professor, University of Wisconsin Medical School 1968- Professor of Biochemistry, Harvard University
1970-73	Chairman, Department of Biochemistry & Molecular Biology Harvard University
1983- Present	Higgins Professor of Biochemistry, Harvard University Scientific member, Dana-Farber Cancer Institute, Harvard Medical School

Title

• Higgins Professor of Biochmistry, Harvard University.

Major Publications and Scientific Papers

• Turner, M.J., Cresswell, P., Parham. P., Strominger, J.L., Mann, D.L., and Sanderson, A.R. Purification and some properties of papain-solubilized histocompatibility antigens from a cultured human lymphoblastoid line, RPMI 4265. J. Biol. Chem. 250: 4512-4519, 1975.
• Orr, H.T., Lopez de Castro, J.A., Lancet, D. and Strominger, J.L. Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies. Biochemistry 18: 5711-5719, 1979.
• Silver, M.L., Guo, H.-C., Strominger, J.L. and Wiley, D.C. Atomic structure of a human MHC molecule presenting an influenza virus peptide. Nature 360: 367-369, 1992.
• Gorga, J., Horejsi, V., Johnson, D., Raghupathy, R. and Strominger, J.L. Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line. J. Biol. Chem. 262: 16087-16094, 1987.
• Gorga, J.C., Brown, J.H., Jardetzky, T., Wiley, D.C., and Strominger, J.L. Crystallization of HLA-DR antigens. Res. Immunol. 142: 401-407, 1991.