Laureates of the Japan Prize


Dr. Anne McLaren

2002 (18th) Japan Prize Laureate

Developmental Biology
Pioneering work on mammalian embryonic development
Commemorative Lecture
Embryos, cells, genes-and Society
Nationality: UK
Date of Birth: 1927
Academic Degrees:
1949 M.A. University of Oxford
1952 Ph.D. University of Oxford
Professional Career:
1952-55 Research Fellow, University College London
1955-59 Research Fellow, Royal Veterinary College of London
1959-74 Member staff, Agricultural Research Council (ARC)
Unit of Animal Genetics, University of Edinburgh
1974-92 Director, Medical Research Council (MRC) Mammalian Development Unit
1991-96 Foreign Secretary, Royal Society
1991 Fullerian Professor of Physiology, Royal Institution
1992-Present Present Principal Research Associate
Wellcome Trust/Cancer Research Campaign (CRC) Institute
1993-94 President, British Association for the Advancement of Science
Title: Principal Research Associate, Wellcome Trust / CRC Institute
Major Publications and Scientific Papers:
  1. McLaren, A. and Biggers, J.D. (1958) Successful development and birth of mice cultivated in vitro as early embryos. Nature 182, 877-878.
  2. McLaren, A. and Michie, D. (1958) Factors affecting vertebral variation in mice.4. Experimental proof of the uterine basis of a maternal effect.JEEM 6, 645-659.
  3. McLaren, A. and Michie, D. (1959) Superpregnancy in the mouse. Implantation and foetal immortality after induced superovulation in females of various ages. J exp Biol 36, 281-300.
  4. Healy, M. J.R., McLaren, A. and Michie, D. (1960) Foetal growth in the mouse. Proc Roy Soc B 153, 367-379. Wellcome Trust/Cancer Research Campaign (CRC) Institute.
  5. McLaren, A. (1964) Immunological control of fertility in female mice. Nature 201, 582-585.
  6. McLaren, A. (1965) Genetic and environmental effects on foetal and placental growth in mice. J Reprod Fert 2, 79-98.
  7. McLaren, A. (1969) Stimulus and response during early pregnancy in the mouse. Nature 221, 739-741.
  8. McLaren, A. and Bowman, P. (1969) Mouse chimaeras derived from fusion of embryos differing by nine genetic factors. Nature 224, 238-240.
  9. McLaren, A. (1972) Numerology of development. Nature 239, 274-276.
  10. McLaren, A. (1975) Sex chimaerism and germ cell distribution in a series of chimaeric mice. J Embryol exp Morph 33, 205-216.
  11. De Felici, M. and Mclaren, A. (1982) Isolation of mouse primordial gem cells. Exp Cell Res 142, 477-482.
  12. McLaren, A., Simpson, E., Tomonari, K., Chandler, P. and Hogg, H. (1984) Male sexual differentiation in mice lacking H-Y antigen. Nature 312, 552-555.
  13. McLaren, A. (1988) The developmental history of female germ cells in mammals. In: Oxford Reviews of Reproductive Biology Chapter 4 Vol. 10, 162-179.
  14. McLaren, A., Simpson, E.,Epplen, J. T., Studer, R., Koopman, P., Evans, E. P., and Burgoyne, P. S., (1988) Location of the genes controlling H-Y antigen expression and testis determination on the mouse Y chromosome. Proc Natl Acad Sci 85, 6442-6445.
  15. McLaren, A. and Buehr, M. (1990) Development of mouse germ cells in cultures of fetal gonads. Cell Differentiation and Development 31, 185-195.
  16. Ginsburg, M., Snow, M. H. L. and McLaren, A. (1990) Primordial germ cells in the mouse embryo gastrulation. Development 110, 521-528.
  17. McLaren, A. (1995) Primordial germ cells in mammals In: Organization of the early vertebrate embryo (eds N Zagris, A M Duprat, A J Duston), Plenum Press, New York, pp.1-9.
  18. McLaren, A. and Southee, D. (1997) Entry of mouse germ cells into meiosis. Dev Biol 187, 107-113.
  19. Durcova-Hills, G., Ainscough, J.E. and McLaren, A. (2001) Pluripotential stem cells derived from migrating primordial cells. Differentiation 68, 220-226.
Major Awards and Honors Received:
  • Scientific Medal, Zoological Society, London (1967)
  • Fellow of the Royal Society (1975)
  • Fellow of the Royal College of Obstetricians and Gynaecologists (1986)
  • Foreign Member of Polish Academy of Sciences (1988)
  • Royal Medal, The Royal Society (1990)
  • Dame Commander of the Order of the British Empire (DBE) (1993)
  • Corresponding Member of Slovenian Academy of Sciences and Arts (1995)
  • Founder Fellow, Academy of Medical Sciences (1998)
  • Foreign Member of the Russian Academy of Sciences (1999)
Membership in Academic Institutions and Societies:
  • The Royal Society
  • Royal Institution 3. British Society for Developmental Biology
  • Genetical Society
  • Society for the Study of Fertility
  • Zoological Society of London
  • British Society for Population Studies
  • ational Mouse Club
  • uropean Molecular Biology Organisation
  • European Society for Human Reproduction and Embryology
  • International Society of Differentiation

( At the time of receipt of the Prize )

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