Laureates of the Japan Prize


Dr. Seiji Ogawa

2003 (19th) Japan Prize Laureate

Visualizing Techniques in Medicine
Discovery of the principle for functional magnetic resonance imaging
Commemorative Lecture
A Way to Learn Brain Function
Nationality: Japan
Date of Birth: January 19 1934
Academic Degrees:
1957 B.S. The University of Tokyo
1967 Ph.D. Stanford University
Professional Career:
1962-64 Research Associate, Radiation Research Laboratories
Mellon Institute, Pittsburgh
1968-80 Member of the Technical Staff, Biophysics Research
Bell Laboratories, AT & T
1984-96 Distinguished Member of the Technical Staff
Principal Investigator
Biophysics Research
1996-2001 Distinguished Member of the Technical Staff
Principal Investigator
Biological Computation Research
Bell Laboratories, Lucent Technologies
2001 March Visiting Professor, Biophysics/Physiology Department
Albert Einstein College of Medicine, Yeshiva University, Bronx, New York
2001- Present Director, Ogawa Laboratories for Brain Function Research
Hamano Life Science Research Foundation
Title: Director, Ogawa Laboratories for Brain Function Research, Hamano Life Science Research Foundation
Major Books and Papers:
  1. S. Ogawa, H. M. McConnell and R. Horowitz, "Overlapping Conformation Changes in Spin-Label Hemoglobin", Proc. Natl. Acad. Sci. (USA), 61: 401-405 (1968)
  2. R. G. Shulman, S. Ogawa, K. Wurthrich, T. Yamane, J. Peisach and W. E. Blumberg, "Absence of "Heme-Heme" Interaction in Hemoglobin", Science, 165: 251-257 (1969)
  3. S. Ogawa and R. G. Shulman, "High Resolution Nuclear Magnetic Resonance Spectra of Hemoglobin:III The Half Ligated State and Allosteric Interaction", J. Mol. Biol., 70: 314-335 (1972)
  4. S. Ogawa, T. M. Lee, A. S. Nayak and P. Glynn, "Oxygenation Sensitive Contrast in Magnetic Resonance Image of Rodent Brain at High Magnetic Fields", Magn. Reson. Med., 14: 68-78 (1990).
  5. S. Ogawa, T. M. Lee, A. R. Kay and D. W. Tank, "Brain Magnetic Resonance Imaging with Contrast Dependent on Blood Oxygenation", Proc. Natl. Acad. Sci. (USA), 87: 9868-9872 (1990).
  6. S. Ogawa, D. W. Tank, R. Menon, J. M. Ellermann, S.-G. Kim, H. Merkle and K. Ugurbil, "Intrinsic Signal Changes Accompanying Sensory Stimulation: Functional BrainMapping With Magnetic Resonance Imaging", Proc. Natl. Acad. Sci. (USA), 89: 5951-5955 (1992).
  7. W. Denk, R. M. Keolian, S. Ogawa and L. W. Jelinski, "Oscillatory Flow in the Cochlea Visualized by Novel Magnetic Resonance Imaging Technique", Proc. Natl. Acad. Sci. (USA), 90: 1595-1598 (1993).
  8. S. Ogawa, R. S. Menon, D. W. Tank, S-G. Kim, H. Merkle, J. M. Ellermann and K. Ugurbil, "Functional Brain Mapping by Blood Oxygenation Level-Dependent Contrast Magnetic Resonance Imaging: A Comparison of Signal Characteristics with a Biophysical Model", Biophysical Journal, 64: March (1993)
  9. P. P. Mitra, S. Ogawa, X. Hu and K. Ugurbil, "The Nature of Spatiotemporal Changes in Cerebral Hemodynamics as Manifested in Functional Magnetic Resonance Imaging",Magnetic Resonance in Medicine, 37: 511-518 (1997)
  10. Seiji Ogawa, Tso-Ming Lee, Ray Stepnoski, Wei Chen, Xiao-Hong Zhu, and Kamil Ugurbil, "An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds", Proc. Natl. Acad. Sci. (USA), 97: 11026-11031 (2000)
Major Awards and Honors Received:
  • Eastman Kodak Award in Chemistry for PhD student (1967)
  • Gold Medal Award from Society of Magnetic Resonance in Medicine (1995)
  • Biological Physics Prize from The American Physical Society (1996)
  • Nakayama Prize from Nakayama Foundation for Human Science, Japan (1998)
  • Asahi Prize from The Asahi Shimbun Cultural Foundation, Japan (1999)
Membership in Academic Institutions and Societies:
  • Member of International Society of Magnetic Resonance in Medicine
  • Member of Society for Neuroscience

( At the time of receipt of the Prize )

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