Japan Prize Laureates

Laureates of the Japan Prize

Dr. Tadamitsu Kishimoto

Dr. Tadamitsu Kishimoto

  • Nationality:
  • Date of Birth:
    7 May 1939

Outline of Achievements

Outline of Achievements

The 2011 Japan Prize

  • Field:
    Bioscience and Medical Science
  • Achievement:
    Discovery of interleukin-6 and its application in treating diseases

Major Honors

1982 Behring-Kitasato Prize
1983 Osaka Science Prize
1986 Erwin von Bälz Prize
1988 Takeda Prize, Asahi Prize
1990 Prize of the Japanese Medical Association, Person of Cultural Merits JAPAN
1991 Scientific Achievement Award from the International Association of Allergology and Clinical Immunology
1992 Imperial Prize from the Japan Academy Sandoz Prize for Immunology from the International Union of Immunological Society (along with Dr. Toshio Hirano)
1995 Member, the Japan Academy
1996 The Avery-Landsteiner Prize from the German Immunology Society
1998 The Order of Culture from Emperor
1999 The Donald Seldin Award from the International Society of Nephrology
2000 ISI Citation Laureate Award, 1981-1988
2003 Robert Koch Gold Medal from the Koch Foundation of Germany
2006 Honorary Life Time Achievement Awards (International Cytokine Society)
2009 The Crafoord Prize from the Royal Swedish Academy of Sciences (along with Dr. Toshio Hirano)
2010 President's Award from the Clinical immunology society of United States


1991 Foreign Associate of the US National Academy of Sciences
1991 President of the Japanese Society for Immunology
1991 President of the International Congress of Immunopharmacology
1992 Honorary member of The American Association of Immunologists
1994 President of the International Society for Interferon and Cytokine Research
1995 Member of the Japan Academy
1997 President of the Japanese Society for Immunology
1997 President of the Japanese Society of Allergology
1997 President of the Japan Society for Clinical Immunology
1997 Honorary member of the American Society of Hematology
1997 Foreign member of the Institute of Medicine of the US National Academy of Sciences
2002 Vice President of the Japanese Medical Association
2005 Member, Deutsche Akademie der Naturforscher Leopoldina
2007 President of the 27th General Assembly of the Japanese Medical Association
2010 President of the 14th International Congress of Immunology

Academic Degrees

1964 Bachelor of Medicine, Osaka University
1969 Ph.D. in Medicine, Osaka University

Professional Career

1969 Assistant researcher of Biochemistry in Faculty of Dental Science, Kyushu University
1970 Research fellow and Visiting Assistant Professor, Johns Hopkins University, U.S.A
1974 Assistant Professor of Medicine, Osaka University
1979 Professor of Medicine, Osaka University
1983 Professor at Institute for Molecular and Cellular Biology, Osaka University
1991 Professor of Medicine, Osaka University
1995 Dean of Faculty of Medicine, Osaka University
1997 President of Osaka University
2004 Member of Council for Science and Technology Policy
2006 Endowed Chair Professor at School of Frontier Biosciences, Osaka University
2007 President, Senri Life Science Foundation


  • Emeritus Professor, Osaka University

Major Publications

  • Hirano T, Yasukawa K, Harada T, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, Tsunasawa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 1986; 324: 73-76.
  • Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 1988; 332:83-85.
  • Yamasaki K, Taga T, Hirano Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T. Cloning and expression of human interleukin 6 (BSF-2/IFNb2) receptor. Science 1988; 241: 825-828.
  • Hirano T, Matsuda T, Turner M, Miyasaka N, Buchan G, Tang B, Sato K, Shimizu M, Maini R, Feldmann M, Kishimoto T. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol. 1988; 18: 1797-1801.
  • Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 1989; 58: 573-581.
  • Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T. Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 1990; 63: 1149-1157.
  • Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor: a paradigm for cytokines. Science 1992; 258: 593-597.
  • Nishimoto N, Yoshizaki K, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Hashimoto J, Azuma J, Kishimoto T. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 antibody: a multicenter double-blind, placebo-controlled trial. Arthritis Rheum 2004; 50: 1761-1769.
  • Nishimoto N, Kishimoto T. Interleukin 6: from bench to bedside. Nat Clin Pract Rheumatol. 2006; 2: 619-626.
  • Yokota S, Imagawa T, Mori M, Miyamae T, Aihara Y, Takei S, Iwata N, Umebayashi H, Murata T, Miyoshi M, Tomiita M, Nishimoto N, Kishimoto T. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet 2008; 371: 998-1006.
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