The 2015 Japan Prize

• Field:
  Medical Science and Medicinal Science
• Achievement:
  Proposal of the concept of gene therapy and its clinical applications
• Lecture:
  Gene therapy, from primary immunodeficiencies to diversified indications

Major Honors

1984	Halpern Prize
1992	Prix Behring-Metchnikoff
1994	Prix du Comité du Rayonnement français
1998	Jung Prize for Medicine (Hamburg)
2000	Prix Pierre Royer
2000	NRJ Foundation – Institut de France – Award
2001	Joint winner of the Louis-Jeantet Prize for Medicine
2001	Novartis Prize for Clinical Immunology
2003	A. Philipson Prize (Stockholm)
2005	Honorary Degree of the University of Zurich
2005	Descartes Prize (European Community)
2008	INSERM Grand Prix
2010	Officier de la Légion d'honneur
2011	Senior advanced grant from ERC (European Research Council)
2012	Avery Landsteiner prize
2013	Grand prix Claude Bernard de la ville de Paris
2013	Sanofi-Pasteur prize
2014	Robert Koch prize

Memberships

2002	Member of the European Molecular Biology Organization
2002	Member of the French Academy of Science
2009	Member of the Academia Europea

Academic Degrees

1979	M.D. from Université Paris Descartes
1979	Ph.D. from Université Paris Jussieu

Professional Career

1980-1981	Postdoctoral fellowship in Immunology at University College London
1981-1991	Group leader – Institut national de la santé et de la recherche médicale (INSERM) Unit 132, Hôpital Necker-Enfants malades, Paris
1984-1988	Tenured clinical position in the Pediatric Immunology Department, Hôpital Necker-Enfants malades
1988-2013	Professor of Pediatric Immunology (Université Paris Descartes)
1991-2013	Director of INSERM Unit 768 for “Développement Normal et Pathologique du Système Immunitaire (Normal and pathological development of the immune system),” Hôpital Necker-Enfants malades, Université Paris Descartes
1996-2012	Director of Pediatric Immunology Department, Hôpital Necker-Enfants malades
2006-present	Professor at Institut Universitaire de France
2007-present	Director of Institut Imagine (Institut des maladies génétiques), Hôpital Necker-Enfants malades, Université Paris Descartes, Inserm U1163
2014-present	Professor at Collège de France (chaire de médecine expérimentale)

Affiliation

• Institut Imagine
  24 Boulevard Montparnasse
  785015 Paris, France

Major Publications

• Stephan V, Wahn V, Le Deist F., Dirksen U, Broker B., Muller-Fleckenstein I, Horneff G. Schroten H., Fischer A, de Saint Basile G. Atypical X-linked severe combined immunodeficiency due to possible spontaneous reversion of the genetic defect in T cells. New Engl J Medecine 335(21):1563-1567, 1996
• Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, Gross F, Yvon E, Nusbaum P, Selz F, Hue C, Certain S, Casanova JL, Bousso P, Deist FL, Fischer A. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288(5466): 669-672, 2000.
• Hacein-Bey-Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, De Villartay JP, Thrasher AJ, Wulffraat N, Sorensen R, Dupuis-Girod S, Davies EG, Kuis W, Leiva L, Fischer A, Cavazzana-Calvo M. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med 346(16): 1185-1193, 2002.
• Hacein-Bey-Abina S, von Kalle C, Schmidt M, Le Deist F, Wulffraat N, McIntyre E, Radford I, Villeval JL, Fraser CC, Cavazzana-Calvo M, Fischer A. A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 348(3): 255-256, 2003.
• Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A*, Cavazzana-Calvo M*. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302(5644): 415-419, 2003. * cosenior authors
• Hacein-Bey-Abina S, Hauer J, Lim A, Picard C, Wang GP, Berry CC, Martinache C, Rieux-Laucat F, Latour S, Belohradsky BH, Leiva L, Sorensen R, Debré M, Casanova JL, Blanche S, Durandy A, Bushman FD, Fischer A*, Cavazzana-Calvo M*. Efficacy of gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 363(4): 355-364, 2010. * cosenior authors
• Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Bleesing J, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, de Oliveira S, Fernandez KS, Guo D, Harris CE, Hopkins G, Lehmann LE, Lim A, London WB, van der Loo JC, Malani N, Male F, Malik P, Marinovic MA, McNicol AM, Moshous D, Neven B, Oleastro M, Picard C, Ritz J, Rivat C, Schambach A, Shaw KL, Sherman EA, Silberstein LE, Six E, Touzot, Tsytsykova A, Xu-Bayford J, Baum C, Bushman FD*, Fischer A*§, Kohn DB*, Filipovich AH*, Notarangelo LD*, Cavazzana M*, Williams DA*§, Thrasher AJ*. A modified gamma-retrovirus vector for X-linked severe combined immunodeficiency. News Engl J Med 371(15):1407-1417,2014* cosenior authors; § cocoresponding authors