The 2021 Japan Prize

• Field:
  Medical Science, Medicinal Science
• Achievement:
  For their pioneering work in conceptualizing a multi-step model of carcinogenesis and its application and impact on improving cancer diagnosis and therapy
• Lecture:
  Cancer Genes & Their Implications for Patients

Award and Honor

1990	Bristol Myers Squibb Award
1992	Canada Gairdner International Award American Cancer Society Medal of Honor
1993	Shacknai Memorial Prize Baxter Award Pezcoller Foundation Award Richard Lounsbery Award
1994	Ernst Schering Prize Dickson Prize, Howard Taylor Ricketts Award Passano Award
1995	Karnofsky Memorial Award, Clowes Memorial Award
1997	William Beaumont Prize Golden Plate Award
1998	Louisa Gross Horwitz Prize William Allan Award Paul Ehrlich and Ludwig Darmstaedter Prize
2000	Charles S. Mott Prize
2001	Harvey Prize
2003	John Scott Award
2004	Prince of Asturias Awards
2007	Pasarow Award
2011	Charles Rodolphe Brupbacher Prize
2013	Breakthrough Prize
2014	Warren Triennial Prize
2015	Paul Janssen Award
2018	Dan David Prize
2019	Albany Medical Center Prize Gruber Prize in Genetics
2020	Jessie Stevenson Kovalenko Medal

Education

1974	M.D. Johns Hopkins University School of Medicine

Professional History

1976-1978	Research associate, National Cancer Institute
1978	Assistant professor, Johns Hopkins University
1989	Professor, Johns Hopkins University
1995	Investigator, Howard Hughes Medical Institute
2012	Co-director, Ludwig Center for at Johns Hopkins
2019	Director, Lustgarten Dedicated Laboratory for Pancreatic Cancer Research

Key Publications

• Vogelstein, B., Fearon, E.R., Hamilton, S.R., Kern, S.E., Preisinger, A.C., Leppert, M., Nakamura, Y., White, R., Smits, A.M.M., Bos, J.L. Genetic alterations during colorectal tumor development. New England Journal of Medicine 319: 525-532, 1988.
• Baker, S.J., Fearon, E.R., Nigro, J.M., Hamilton, S.R., Preisinger, A.C., Jessup, J.M., vanTuinen, P., Ledbetter, D.H., Barker, D.F., Nakamura, Y., White, R., Vogelstein, B. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 244: 217-221, 1989.
• Nishisho, I., Nakamura, Y., Miyoshi, Y., Miki, Y., Ando, H., Horii, A., Koyama, K., Utsunomiya, J., Baba, S., Hedge, P., Markham, A., Krush, A.J., Petersen, G., Hamilton, S.R., Nilbert, M.C., Levy, D.B., Bryan, T.M., Preisinger, A.C., Smith, K.J., Su, L.-K., Kinzler, K.W., Vogelstein, B. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253: 665-669, 1991.
• Kern, S.E., Kinzler, K.W., Bruskin, A., Jarosz, D., Friedman, P., Prives, C., Vogelstein, B. Identification of p53 as a sequence-specific DNA-binding protein. Science 252: 1708-1711, 1991.
• Sidransky, D., Tokino, T., Hamilton, S.R., Kinzler, K.W., Levin, B., Frost, P., and Vogelstein, B. Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science 256: 102-105, 1992.
• Wood, L.D., Parsons, D.W., Jones, S., Lin, J., Sjöblom, T., Leary, R,J., Shen, D., Boca, S.M., Barber, T., Ptak, J., Silliman, N., Szabo, S., Dezso, Z., Ustyanksky, V., Nikolskaya, T., Nikolsky, Y., Karchin, R., Wilson, P.A., Kaminker, J.A., Zhang, Z., Croshaw, R., Willis, J., Dawson, D., Shipitsin, M., Willson, J.K.V., Sukumar, S., Polyak, K., Park, B.H., Pethiyagoda, C.L., Pant, P.V.K., Ballinger, D.G., Sparks, A.B., Hartigan, J., Smith, D. R., Suh, E., Papadopoulos, N., Buckhaults, P., Markowitz,S.D., Parmigiani, G., Kinzler, K.W., Velculescu, V.E. and Vogelstein, B. The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113, 2007.