The 2021 Japan Prize

• Field:
  Medical Science, Medicinal Science
• Achievement:
  For their pioneering work in conceptualizing a multi-step model of carcinogenesis and its application and impact on improving cancer diagnosis and therapy
• Lecture:
  Mechanisms of Malignant Progression

Award and Honor

1983	Robert Koch Foundation Prize Warren Triennial Prize
1984	Bristol-Myers Award Howard Taylor Ricketts Award,
1985	Golden Plate Award
1987	Sloan Prize
1992	Canada Gairdner International Award
1994	Harvey Prize
1996	Pasarow Award Clowes Memorial Award
1997	National Medal of Science, Keio Medical Science Prize
1999	Albert Einstein World Award
2004	Wolf Prize
2006	Landon-AACR Prize
2007	Warburg Medal
2013	Breakthrough Prize
2016	Salk Medal

Education

1964	B.S. Massachusetts Institute of Technology
1969	Ph.D. Massachusetts Institute of Technology

Professional History

1972-1973	Research Associate, MIT
1973-1976	Assistant Professor, MIT
1976-1982	Associate Professor, MIT
1982-	Professor, MIT
1982-	Member, Whitehead Institute for Biomedical Research
2006-	Director, Ludwig Center for Molecular Oncology, MIT

Key Publications

• Shih, C., Shilo, B., Goldfarb, M.P., Dannenberg, A., and Weinberg, RA (1979) Passage of Phenotypes of Chemically Transformed Cells via Transfection of DNA and Chromatin. Proc. Nat'l. Acad. Sci., USA, 76: 5714-5718.
• Tabin, C.J., Bradley, S.M., Bargmann, C.I., Weinberg, RA, Papageorge, A.G., Scolnick, E.M., Dhar, R., Lowy, D.R., and Chang, E.H. (1982) Mechanism of Activation of a Human Oncogene. Nature, 300: 143-149.
• Land, H., Parada, L.F., and Weinberg, RA (1983) Tumorigenic Conversion of Primary Embryo Fibroblasts Requires at Least Two Cooperating Oncogenes. Nature, 304: 596-602.
• Friend, S.H., Bernards, R., Rogelj, S., Weinberg, RA, Rapaport, J.M., Albert, D.M., and Dryja, T.P. (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature, 323: 643-646.
• Yang, J., Mani, S.A., Liu Donaher, J., Richardson, A., Ramaswamy, S., Gitelman, I., and Weinberg, RA (2004) Twist, a master regulator of morphogenesis plays an essential role in tumor metastasis. Cell, 117:927-939.
• Hanahan D and Weinberg RA (2011). Hallmarks of Cancer: The next generation, Cell 144(5) 646-674.